Anna A DePaoli-Roach Selected Research

Lafora Disease

1/2020	Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
1/2017	Novel method for detection of glycogen in cells.
1/2016	Incorporation of phosphate into glycogen by glycogen synthase.
9/2015	Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice.
1/2015	Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease.
7/2014	Protein degradation and quality control in cells from laforin and malin knockout mice.
4/2012	Laforin and malin knockout mice have normal glucose disposal and insulin sensitivity.
4/2011	PTG depletion removes Lafora bodies and rescues the fatal epilepsy of Lafora disease.
3/2011	Phosphate incorporation during glycogen synthesis and Lafora disease.
8/2010	Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin.

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Anna A DePaoli-Roach Research Topics

Disease

11	Lafora Disease 01/2020 - 01/2007
5	Heart Failure 12/2010 - 06/2002
4	Glycogen Storage Disease (Glycogenosis) 01/2022 - 01/2017
3	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 07/2014 - 08/2010
2	Insulin Resistance 01/2017 - 04/2012
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2015 - 01/2008
2	Starvation 07/2014 - 11/2010
2	Cardiomegaly (Heart Hypertrophy) 12/2010 - 10/2008
2	Hypertrophy 12/2010 - 10/2008
1	Glycogen Storage Disease Type II (Pompe's Disease) 01/2017
1	Epilepsy (Aura) 01/2016
1	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2015
1	Neoplasms (Cancer) 08/2009
1	Congenital Heart Defects (Congenital Heart Defect) 08/2004
1	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 03/2004
1	Glucose Intolerance 01/2002

Drug/Important Bio-Agent (IBA)

17	GlycogenIBA 01/2022 - 01/2002
6	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2016 - 06/2002
3	Phosphates (Orthophosphate)IBA 09/2015 - 03/2011
2	EnzymesIBA 01/2017 - 06/2002
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 07/2014 - 08/2010
2	Glucose (Dextrose)FDA LinkGeneric 04/2012 - 11/2010
2	CalciumIBA 12/2010 - 04/2005
2	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 12/2010 - 10/2008
2	Protein Phosphatase 1IBA 04/2005 - 01/2002
1	AcetylglucosamineIBA 01/2021
1	Uridine Diphosphate (UDP)IBA 01/2021
1	PolymersIBA 01/2017
1	AcidsIBA 01/2017
1	alpha-Glucosidases (Acid Maltase)IBA 01/2017
1	Liver GlycogenIBA 01/2017
1	Ubiquitinated ProteinsIBA 07/2014
1	Sirolimus (Rapamycin)FDA Link 07/2014
1	Dual-Specificity PhosphatasesIBA 04/2012
1	Insulin (Novolin)FDA Link 04/2012
1	Proteins (Proteins, Gene)FDA Link 04/2011
1	p21-Activated KinasesIBA 12/2010
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 12/2010
1	polyglucosanIBA 08/2010
1	Phosphotransferases (Kinase)IBA 08/2009
1	cysteine and glycine-rich protein 3IBA 03/2004
1	Protein Isoforms (Isoforms)IBA 01/2002